Contraindication 

Absolute conditions to avoid: 

• Platelet dysfunction syndrome - Platelet function disorders are bleeding disorders in which the platelets do not form a strong blood clot. People with platelet function disorders tend to bleed or bruise more easily. They may have a normal number of platelets or a low platelet count. Their platelet size may be small, normal or large. 
• Critical thrombocytopenia - Dangerous internal bleeding can occur when your platelet count falls below 10,000 platelets per microliter. Though rare, severe thrombocytopenia can cause bleeding into the brain, which can be fatal. 
• Hemodynamic instability - Hemodynamic instability occurs when there's abnormal or unstable blood pressure, which can cause inadequate blood flow to your organs. 
• Septicaemia - Sepsis is a life-threatening reaction to an infection. It happens when your immune system overreacts to an infection and starts to damage your body's own tissues and organs. You cannot catch sepsis from another person. Sepsis is sometimes called septicaemia or blood poisoning. 
• Local infection at the treatment site 
• Resus negative blood type  

General conditions to avoid: 

• Consistent use of Non-steroidal anti-inflammatory drugs (NSAIDS) 48 hours prior but for the best results client must abstain for at least seven days. 
• Client must not have had a corticosteroid injection at the treatment site within one month and that’s to include kenalog or any Cortisone treatment for joint pain. 
• They must stop all steroids for anti-inflammatory conditions or anticoagulants and if they do not then they will more than likely experience bruising. 
• The systemic use of corticosteroids must be halted for two weeks prior to any bio filler treatment.  
• Client should avoid tobacco use because this will contribute to poor healing. 
• The client should not have had a recent illness or fever. 
• Cancer- with specific concerns aimed at hematopoietic and bone cancers. There are several growth factors that our bodies produce that would accelerate the growth of or contribute to the advancement of a cancerous tumour in the late stages.  
• Solid cancers cannot grow beyond a limited size without an adequate blood supply; cancers that can express Vascular Endothelial Growth Factor (VEGF) are able to grow and metastasize. 
• The cytokine Transforming Growth Factor-Beta (TGF-B) contributes to the malignant progression of a late stage tumour.  
• Haemoglobin (HGB) must not be <10g/dl 
• Platelet count must not be <105/ul